The gluteal area should never be used for rabies vaccine injections because observations suggest administration in this area results in lower neutralizing antibody titers. The recommended dose of KEDRAB is 20 IU/kg body weight, given at the time of the first vaccine dose. in 1956 established the dosage of rabies immune globulin. The gluteal area should never be used for rabies vaccine injections because observations suggest administration in this area results in lower neutralizing antibody titers. Dosage of rabies immune globulin was calculated from the victim's body weight, then the amount of rabies immune globulin would be injected as much as possible to all of the wounds. Dosage of RIG ( Rabies Immune Globulin) based on body weight Usual Dosage is 20 IU/KG of body weight or 2 cc per 33 pounds (1cc = 150 IU) (.3cc / 5lbs) Adult Dosages 100 105 6.1cc 6.4cc 20 1.2cc 25 1.5cc Pediatric Dosages Weight in pounds (2cc/33#) Total cc Dosage Weight in pounds (2cc/33#) The predecessor product, HYPERRAB® S/D [rabies immune globulin (human)] was formulated at 150 IU/mL. Beyond the seventh day, Rabies Immune Globulin (Human) is not indicated since an antibody response to cell culture vaccine is presumed to have occurred. This will provide immediate antibodies until the body can respond to the vaccine by actively producing antibodies of its own. The importance of passive immunization was scientifically proved by studies by Habel and Koprowsky conducted five to six decades ago. Dosage of RIG ( Rabies Immune Globulin) based on body weight Usual Dosage is 20 IU/KG of body weight or 2 cc per 33 pounds (1cc = 150 IU) (.3cc / 5lbs) Adult Dosages 100 105 6.1cc 6.4cc 20 1.2cc 25 1.5cc Pediatric Dosages Weight in pounds (2cc/33#) Total cc Dosage Weight in pounds (2cc/33#) These protective antibodies have a half-life of only approximately 21 days. Please read both sides of this document. Limitations of Use . It is preferable that as much as possible of the HRIG is injected in and around the wound site. For children, the anterolateral aspect of the thigh is also acceptable. PEP consists of a single dose of KEDRAB and a full course of rabies vaccine. For adults, the vaccination should always be administered intramuscularly in the deltoid area (arm). 4 World Health Organization strongly recommended use of rabies immunoglobulin in 1973. Rabies Immune Globulin (Human) Hyper RAB ® 900 IU/3 mL Solution for Infiltration and Intramuscular Injection 300 IU/mL Suitable for use with Rabies Vaccine 3 mL NDC 13533-318-03 GRIFOLS One Single-Dose Vial Rabies Immune Globulin (Human) is a sterile solution of immunoglobulin containing 15%–18% protein stabilized with 0.16 to 0.26 M glycine. in 1956 established the dosage of rabies immune globulin. Rabies immune globulin (RabIg) provides immediate passive antibody protection until the exposed person mounts an immune response to the rabies vaccine. 4 World Health Organization strongly recommended use of rabies immunoglobulin in 1973. rabies immune globulin ) increase total serum globulin levels and/or affect a/g ratio on a comprehensive ... to be a coincidence or is rabies vaccine known to increase total globulin level? The treatment of both Rabies Immune Globulin (Human) and vaccine corresponded to the postexposure recommended dose of 20 IU/kg of Rabies Immune Globulin (Human) and was administered in three, equally divided IM injections of under 5 mL in either gluteus. When and where is human rabies immunoglobulin (HRIG) given? HYPERRAB is formulated with a strength of 300 IU/mL. The recommended dose in ml should not be exceeded. KEDRAB and the first dose of rabies vaccine should be given as soon as possible after exposure, as delays are potentially lethal. The volume required of HYPERRAB (300 IU/mL) to achieve Some patients received HRIG, 20 to 30 IU/kg body weight, or Equine Rabies Immune Globulin (ERIG), 40 IU/kg body weight, at the time of the first dose. Human rabies immune globulin (HRIG) is administered only once, at the beginning of anti-rabies prophylaxis, to previously unvaccinated persons. Weight (pounds) 105 115 120 125 130 135 140 145 150 155 160 165 170 175 180 185 200 205 210 215 • Ensure the correct strength is used for the calculation. Increase dosage of rabies immune globulin was needed in situation of multiple severe bite-wounds especially among children whose had lower body weight than adults. 2, 3 Further studies by Atanasiu et al. It provides immunity until the vaccine starts to protect at about day 7. Persons who have been previously immunized with rabies vaccine and have a confirmed adequate rabies antibody titer should receive only vaccine. Rabies Immune Globulin (Human) Hyper RAB ® 300 IU/mL Solution for Infiltration and Intramuscular Injection 300 IU/mL Suitable for use with Rabies Vaccine 1 mL NDC 13533-318-01 GRIFOLS One Single-Dose Vial Rabies Immune Globulin (Human) is a sterile solution of immunoglobulin containing 15%–18% protein stabilized with 0.16 to 0.26 M glycine. The most effective use of RabIg is in the wound.