Pityriasis rosea (PR)-like eruption is a cutaneous complication associated with several medications and vaccinations. -, Welsh E, Cardenas-de la Garza JA, Cuellar-Barboza A, Franco-Marquez R, Arvizu-Rivera RI. 2021 Dec;108(6):317-318. doi: 10.12788/cutis.0411. 2021 Nov;35(11):e721-e722. Inverse pityriasis rosea secondary to COVID-19 vaccination. No one knows what causes pityriasis rosea, though healthcare experts think a virus might be responsible. Authors Lina Abdullah 1 2021 Sep 7;8:752443. doi: 10.3389/fmed.2021.752443. -, Cyrenne BM, Al-Mohammedi F, DeKoven JG, Alhusayen R. Pityriasis rosea-like eruptions following vaccination with BNT162b2 mRNA COVID-19 vaccine. J Eur Acad Dermatol Venereol 2020; 34: e436-e437. Lawley LP, McCall CO, Lawley TJ. Br J Dermatol. Pityriasis rosea-like eruptions following vaccination with BNT162b2 mRNA COVID-19 Vaccine. Nevertheless, the incidence of skin reactions after mRNA vaccinations was low. Please enable it to take advantage of the complete set of features! The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The patients/participants provided their written informed consent to participate in this study. Outcome: 2023 Cond Nast. With COVID-19 vaccines being authorized for emergency use, monitoring for potential adverse effects (e.g., cutaneous reactions) is necessary. This patch is the herald or mother patch. This article presents a case of PR in a 66-year-old black male 1 week after administration of the Pfizer-BioNTech COVID-19 vaccine. Fried foods, including many fast-food items. National Library of Medicine 2020 Jul;33(4):e13730. Those ensuing spots like the circle of dots that erupted on my back a day after the initial raised welt appeared typically resemble a Christmas tree-like formation. Clipboard, Search History, and several other advanced features are temporarily unavailable. Global prevalence and clinical manifestations of cutaneous adverse reactions following COVID-19 vaccination: A systematic review and meta-analysis. Pityriasis Rosea-like eruptions following COVID-19 mRNA-1273 vaccination: A case report and literature review. In approximately 50% of people with pityriasis rosea, the patches itch. The papillary dermis shows melanin incontinence, perivascular lymphocytic infiltrate and rare scattered extravasated red blood cells. We present two cases of COVID-19 vaccine-induced pityriasis rosea. National Library of Medicine Generalized Papulovesicular Eruption as a Side Effect of the Pfizer-BioNTech COVID-19 Vaccine. New York City-based dermatologist Macrene Alexiades. Pityriasis rosea, pityriasis rosea-like eruptions, and herpes zoster in the setting of COVID-19 and COVID-19 vaccination. Authors B M Cyrenne 1 , F Al-Mohammedi 1 , J G DeKoven 1 , R Alhusayen 1 Affiliation The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Considering the actual epidemiological context, we performed a real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay from nasal and pharyngeal swabs for coronavirus disease 2019 (COVID-19) to investigate the PR etiology. Pityriasis rosea following SARS-CoV-2 vaccination: A case series. N Engl J Med 2020; 383: 2603-2615. Pityriasis Rosea Associated With COVID-19 Vaccination: A Common Rash Following Administration of a Novel Vaccine. It's also what's known as a self-limiting rash, Hartman says, in that it can resolve itself on its own without treatment in about six to eight weeks. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753512/), Visitation, mask requirements and COVID-19 information, sexually transmitted disease or infection. Unable to load your collection due to an error, Unable to load your delegates due to an error. Pityriasis rosea-like eruption revealing COVID-19. Get more info about other skin conditions: The Ultimate Guide to Skin Conditions for Black & Brown Folks, I Thought I Just Had Dry Skin, But It Was Actually Perioral Dermatitis, Everything You Should Know About Hidradenitis Suppurativa. Some treatments can alleviate related symptoms, including itching. It has been reported that pityriasis rosea has been triggered by several vaccines, as a rare side-effect. Please enable it to take advantage of the complete set of features! Epub 2022 Jul 19. 2022 May;11(2):222-225. doi: 10.7774/cevr.2022.11.2.222. -, Neoh CY, Tan AW, Mohamed K, et al. FOIA Martora F, Battista T, Marasca C, Genco L, Fabbrocini G, Potestio L. Clin Cosmet Investig Dermatol. Federal government websites often end in .gov or .mil. How do dermatologists treat pityriasis rosea? Careers. We do not endorse non-Cleveland Clinic products or services. It is increasingly recognized that SARS-CoV-2 infection and COVID-19 vaccines have been associated with skin disorders, including pityriasis rosea. 2021 Sep;60(9):1150-1151.doi: 10.1111/ijd.15700. This tiny glimpse of her natural texture is thrilling. Marzano AV, Cassano N, Genovese G, Moltrasio C, Vena GA. Cutaneous manifestations in patients with COVID19: a preliminary review of an emerging issue. eCollection 2022 Jul. "Other treatments including phototherapy or oral medications can be considered for extensive or persistent cases, [and] some small case studies support the use of oral antivirals like acyclovir or oral anti-inflammatory antibiotics erythromycin," King explains. Sprinkle bath water with an oatmeal-based bath product (Aveeno). J Formos Med Assoc. Additional evidence that pityriasis rosea is associated with reactivation of human herpesvirus-6 and -7. One case of pityriasis rosea is reported in a patient infected with COVID-19, and the most commonly reported features are exanthomatous rash, urticaria, chickenpox like vesicles, petechiae, and acute hemorrhagic edema of infancy. Among 171 laboratory-confirmed COVID-19 patients with cutaneous manifestations from the registry, the most commonly reported were morbilliform rash (22 percent), pernio-like acral lesions (18 percent), urticaria (16 percent), macular erythema (13 percent), vesicular eruption (11 percent), papulosquamous eruption (9.9 percent), and retiform The good news is many of those who develop pityriasis rosea never get it again, says New York City-based dermatologist Hadley King. COVID-19-associated pityriasis rosea in children: Case report and literature review. Pityriasis is linked mainly with herpesviruses 6 and 7; only a . Pityriasis Rosea Associated With COVID-19 Vaccination: A Common Rash Following Administration of a Novel Vaccine. -, Johansen M, Chisolm SS, Aspey LD, Brahmbhatt M. Pityriasis rosea in otherwise asymptomatic confirmed COVID-19-positive patients: a report of 2 cases. 2021 Dec;108(6):317-318. doi: 10.12788/cutis.0411. MeSH Ehsani AH, Nasimi M, Bigdelo Z. Pityriasis rosea as a cutaneous manifestation of COVID-19 infection. Herald patch in the right hypochondrium followed by typical oval-shaped secondary plaques, Pityriasis rosea lesions on the upper extremities, MeSH When to test for COVID-19 using real-time reverse transcriptase polymerase chain reaction: a systematic review. Would you like email updates of new search results? Moreover, almost all lesions faded with associated post-inflammatory hyperpigmentation (Figure 2B). -. Adverse cutaneous reactions following COVID-19 vaccines have increased, highlighting not only how SARS-CoV-2 infection but also COVID-19 vaccines may induce adverse cutaneous manifestations. eCollection 2022. Drago F, Ciccarese G, Rebora A, et al. official website and that any information you provide is encrypted . Atypical pityriasis rosea associated with mRNA COVID19 vaccine E. Bostan, Adam Jarbou Published 29 September 2021 Medicine Journal of Medical Virology Variable dermatological manifestations including acral erythema, urticaria, vasculitis, vesicular or pustular eruptions, maculopapular rash have all been reported during the course of Covid-19. The average time between vaccination and rash onset is 10 days, and most patients experience pruritus (70%). . Br J Dermatol 2021. official website and that any information you provide is encrypted Cutaneous Reactions Following COVID-19 Vaccination: A Review of the Current Literature. Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: a registry-based study of 414 cases. Six cases of pityriasis rosea following SARS-CoV-2 vaccination with BNT162b2. You also wont have permanent scarring or other damage to your skin. Borgia F, Li Pomi F, Alessandrello C, Vaccaro M, Pioggia G, Gangemi S. J Dermatol. If you need help purchasing a product directly from Allure, go to our FAQ. Cutaneous Reactions Following COVID-19 Vaccination: A Review of the Current Literature. The patches may itch. Unable to load your collection due to an error, Unable to load your delegates due to an error. Proc (Bayl Univ Med Cent). Pityriasis rosea-like eruption after Pfizer-BioNTech COVID-19 vaccination. Accessibility Before See your skin clear. Although histopathologic characteristics of PR are also observed in PR-like lesions, the presence of dyskeratotic keratinocytes, interface dermatitis, and eosinophilic infiltration in the dermis may be more prominent in PR-like eruptions (11). Vaccinations have been identified to rarely cause several cutaneous reactions. 8600 Rockville Pike They were found on hands and feet, showing up as red or purple spots caused by bleeding under the skin. 2021 Dec;108(6):317-318. doi: 10.12788/cutis.0411. Some people who have had cosmetic fillers used to remove . Cutaneous Eruptions in the Course of COVID-19 Among Geriatric Patients in a Nursing Home in Poland. However, several adverse effects of COVID-19 vaccination have been identified. (2021) 93:18501. (2021) 35:e4913. 2022 Feb 3;9 (2):003164. doi: 10.12890/2022_003164. Please enable it to take advantage of the complete set of features! 2021;185(2):e34. The https:// ensures that you are connecting to the 2022 Dec;9:127. doi: 10.1016/j.jdin.2022.03.018. NCI CPTC Antibody Characterization Program, Ritchie H., Mathieu E., Rodes-Guirao L., et al. The patient presented to the Department of Dermatology for a 3 week duration of an extremely pruritic erythematous-squamous lesion, initially on the trunk and upper limbs, with extension to the lower limbs in the last week and the lesion respected the cephalic extremity, palms, and soles. It is likely that a new viral trigger of pityriasis rosea is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, pityriasis rosea can look similar to other skin conditions, including: If theres any doubt, your healthcare provider may perform the following tests: In most cases, pityriasis rosea goes away without any treatment in six to eight weeks. Epstein-Barr virus reactivation after COVID-19 vaccination in a young immunocompetent man: a case report. (2017) 5:20311. You may initially develop a fever, headache or upper respiratory infection. Epub 2021 May 29. eCollection 2022. Cutaneous Reactions Following COVID-19 Vaccination: A Review of the Current Literature. The .gov means its official. doi: 10.1111/dth.13650, 7. The site is secure. Pityriasis rosea developing after COVID-19 vaccination. Ciccarese G, Parodi A, Drago F. SARS-CoV-2 as possible inducer of viral reactivations. 2022 Jun;7:164-168. doi: 10.1016/j.jdin.2022.01.009. In my experience, patients with darker skin are more likely to present with atypical forms of the disorder. The https:// ensures that you are connecting to the Washrawirul C, Triwatcharikorn J, Phannajit J, Ullman M, Susantitaphong P, Rerknimitr P. J Eur Acad Dermatol Venereol. Epub 2022 Feb 9. Cutaneous Complications of mRNA and AZD1222 COVID-19 Vaccines: A Worldwide Review. eCollection 2022. doi: 10.1016/j.jaad.20.2103.092. Careers. official website and that any information you provide is encrypted 2021 Jun 25;118(25):431. doi: 10.3238/arztebl.m2021.0257. Bethesda, MD 20894, Web Policies Dermatol Ther. It often presents with diffuse and confluent severely pruritic dusky-red erythematous lesions in the absence of herald patch (11). Get many smaller patches or bumps on your skin. Int J Dermatol. I tell my patient to use a gentle non-soap cleanser." J Eur Acad Dermatol Venereol. The following self-care tips may help relieve the discomfort of pityriasis rosea: Take nonprescription allergy medicine (antihistamines), such as diphenhydramine (Benadryl, others). Interventions: Pityriasis Rosea Following Pfizer-BioNTech Vaccination in an Adolescent Girl. Abdullah L, Hasbani D, Kurban M, Abbas O. Pityriasis rosea after mRNA COVID-19 vaccination. government site. Cyrenne BM, Al-Mohammedi F, DeKoven JG, Alhusayen R. Pityriasis rosea-like eruptions following vaccination with BNT162b2 mRNA COVID-19 vaccine. A 3-cm oval plaque with peripheral scale, larger than the other lesions, was present on the inferior portion of the right breast. A virus may cause pityriasis rosea, but experts arent sure. Our experience with 80 cases of SARS-CoV-2-Clostridioides difficile co-infection: An observational study. Unauthorized use of these marks is strictly prohibited. A more recent letter in the International Journal of Dermatology reported a "unique case of pityriasis rosea following administration of mRNA COVID-19 vaccine." 8600 Rockville Pike Int J Infect Dis. It has been reported that pityriasis rosea has been triggered by several vaccines, as a rare side-effect. Khalili M, Abtahi-Naeini B, Rastegarnasab F, Afshar K. Clin Case Rep. 2022 Jul 19;10(7):e6096. These conditions lasted 8.6 days on average. J Formos Med Assoc. Advertising on our site helps support our mission. 2021 Aug;35(8):e491-e493. Pityriasis rosea, COVID-19 and vaccination: new keys to understand an old acquaintance. National Library of Medicine "And it has a particular [dermatomal] distribution because it's along a nerve," which also presents as fluid-filled blisters, rather than lesions. The .gov means its official. doi: 10.1111/dth.13730. J Eur Acad Dermatol Venereol. Int J Dermatol. Despite this rare complication, our report highlights that the presence of PR-like eruption is not a contraindication for subsequent vaccinations. doi: 10.1111/bjd.20143. The site is secure. Pityriasis rosea is a benign inflammatory rash that starts with a single red rash, also known as the "herald patch," which eventually gives way to a larger, similar-looking rash on the trunk within days or weeks, says dermatologist Corey L. Hartman, founder of Skin Wellness Dermatology in Birmingham, Alabama. Cyrenne BM, Al-Mohammedi F, DeKoven JG, Alhusayen R. J Eur Acad Dermatol Venereol. 2022 Jan;114:88-89. doi: 10.1016/j.ijid.2021.10.055. and transmitted securely. (2020) 33:e13650. McMahon DE, Amerson E, Rosenbach M, Lipoff JB, Moustafa D, Tyagi A, et al. Appointments 216.444.5725 Appointments & Locations Request an Appointment Physicians should be aware that pityriasis rosea is a rare side-effect of COVID-19 vaccination.Pityriasis rosea is self-limiting and no medical treatment is usually required. FOIA Pityriasis Rosea as a Possible Complication of Vaccination Against COVID-19. Epub 2021 May 29. Ad Choices. It should clear your body in six to eight weeks. Similar to other viral outbreaks, people can experience flu-like symptoms like a fever, aches, or a runny nose when the herald patch shows up, Lam says, though I was lucky enough to skip that step. doi: 10.1111/jdv.17342. Bethesda, MD 20894, Web Policies Bookshelf Martn Enguix D, Salazar Nievas MDC, Martn Romero DT. (2021) 60:11501. No use, distribution or reproduction is permitted which does not comply with these terms. What started as a single, quarter-inch raised welt on my left rib cage eventually morphed into two, then four. Epub 2022 Jun 21. Children often get infected when someone sneezes or kisses them. Pityriasis Rosea According to the Mayo Clinic, pityriasis rosea is a rash that usually begins as a large circular or oval spot on your chest, abdomen, or back. An official website of the United States government. Bethesda, MD 20894, Web Policies Clinical findings of pityriasis rosealike eruption in the patients. MeSH Human herpesviruses 6 and 7 are common. Cutis. Lasers Med Sci. See this image and copyright information in PMC. An official website of the United States government. 2022 Aug;20(8):1123-1124. doi: 10.1111/ddg.14784. doi: 10.1002/ccr3.6096. Pityriasis rosea (PR)-like eruption is a cutaneous complication associated with several medications and vaccinations. This site needs JavaScript to work properly. Now watch a pro surfer's entire daily routine: Follow Allure onInstagram andTwitter, orsubscribe to our newsletter to stay up to date on all things beauty. 2022 Feb 20;14(2):e22414. Disclaimer. Few brownish patches also appeared, suggestive of post-inflammatory hyperpigmentation. (2019) 34:185764. Keywords: 2022 Jan;114:88-89. doi: 10.1016/j.ijid.2021.10.055. As King notes, there have been some reported cases of pityriasis rosea occurring in patients after receiving certain vaccines, like the flu shot. 2023 Feb 9;11(2):397. doi: 10.3390/vaccines11020397. HHS Vulnerability Disclosure, Help retailers. Other plausible theories include molecular mimicry with viral epitopes and type IV delayed hypersensitivity reaction (12). The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS).