The best-understood role of cyclic AMP in bacteria is to modulate the utilization of carbon sources. Cyclic AMP was identified in bacteria in 1965, also by Sutherland. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Seems to function synergistically with ATF6. In vitro, binds to the cAMP response element (CRE) and box-B element. In cell biology, protein kinase A (PKA) is a family of enzymes whose activity is dependent on cellular levels of cyclic AMP (cAMP). Our cAMP ELISA Kits provide a highly sensitive method to measure low levels of cyclic AMP in a variety of sample types. Activation of protein kinase A (PKA) by cyclic AMP (cAMP) is a conserved feature of eukaryotic signaling systems. Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Cyclic AMP binds to protein kinase A, which then catalyzes the transfer of phosphate from ATP to a serine residue on a second enzyme, phosphorylase kinase, which itself transfers a phosphate to glycogen The unique characteristic of protein kinase A is that its activity is regulated by fluctuating levels of cyclic AMP within cells (hence its alias as the cyclic AMP-dependent protein kinase). Start studying Second-Messenger Systems: Cyclic AMP (cAMP). 1970;39:335-343.Crossref. Cyclic adenosine monophosphate (cAMP) was the original “second messenger” to be discovered. Cyclic AMP (cAMP) is an important regulatory molecule in the GPCR signaling cascade. The cyclic GMP–AMP synthase (cGAS)–STING pathway is a central component of the cell-autonomous innate immune system in animals1,2. cyclic AMP n. Abbr. Kumon A, Yamamura H, Nishizuka Y. Mode of action of adenosine 3′,5′-cyclic phosphate on protein kinase from rat liver . "Cyclic AMP Receptor Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. Activates transcription through box-B element. Activated in response to cAMP stimulation. Activates transcription through CRE (By similarity). Instead, cyclic AMP stimulates a protein kinase cascade that ultimately leads to a cellular response. This enzyme thus functions as the end effector for a variety of hormones that work through a cyclic AMP signalling pathway. A cyclic-3′,5′-adenosine monophosphate-dependent protein kinase from the adrenal cortex: comparison with a cyclic AMP binding protein . Cyclic AMP is a specific marker of circulating PTH: 90% of patients with hyperparathyroidism show increased levels of nephrogenic cAMP.